The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes.
Identifieur interne : 000038 ( Main/Exploration ); précédent : 000037; suivant : 000039The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes.
Auteurs : Rita Citraro [Italie] ; Michele Navarra [Italie] ; Antonio Leo [Italie] ; Eugenio Donato Di Paola [Italie] ; Ermenegildo Santangelo [Italie] ; Pellegrino Lippiello [Italie] ; Rossana Aiello [Italie] ; Emilio Russo [Italie] ; Giovambattista De Sarro [Italie]Source :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2016.
Abstract
The usage of dietary supplements and other natural products to treat neurological diseases has been growing over time, and accumulating evidence suggests that flavonoids possess anticonvulsant properties. The aim of this study was to examine the effects of a flavonoid-rich extract from orange juice (OJe) in some rodent models of epilepsy and to explore its possible mechanism of action. The genetically audiogenic seizures (AGS)-susceptible DBA/2 mouse, the pentylenetetrazole (PTZ)-induced seizures in ICR-CD1 mice and the WAG/Rij rat as a genetic model of absence epilepsy with comorbidity of depression were used. Our results demonstrate that OJe was able to exert anticonvulsant effects on AGS-sensible DBA/2 mice and to inhibit PTZ-induced tonic seizures, increasing their latency. Conversely, it did not have anti-absence effects on WAG/Rij rats. Our experimental findings suggest that the anti-convulsant effects of OJe are likely mediated by both an inhibition of NMDA receptors at the glycine-binding site and an agonistic activity on benzodiazepine-binding site at GABAA receptors. This study provides evidences for the antiepileptic activity of OJe, and its results could be used as scientific basis for further researches aimed to develop novel complementary therapy for the treatment of epilepsy in a context of a multitarget pharmacological strategy.
DOI: 10.3390/molecules21091261
PubMed: 27657037
Affiliations:
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erusso@unicz.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Science of Health, School of Medicine and Surgery, University of Catanzaro, Catanzaro I-88100</wicri:regionArea><wicri:noRegion>Catanzaro I-88100</wicri:noRegion></affiliation></author><author><name sortKey="De Sarro, Giovambattista" sort="De Sarro, Giovambattista" uniqKey="De Sarro G" first="Giovambattista" last="De Sarro">Giovambattista De Sarro</name><affiliation wicri:level="1"><nlm:affiliation>Department of Science of Health, School of Medicine and Surgery, University of Catanzaro, Catanzaro I-88100, Italy. desarro@unicz.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Science of Health, School of Medicine and Surgery, University of Catanzaro, Catanzaro I-88100</wicri:regionArea><wicri:noRegion>Catanzaro I-88100</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The usage of dietary supplements and other natural products to treat neurological diseases has been growing over time, and accumulating evidence suggests that flavonoids possess anticonvulsant properties. The aim of this study was to examine the effects of a flavonoid-rich extract from orange juice (OJe) in some rodent models of epilepsy and to explore its possible mechanism of action. The genetically audiogenic seizures (AGS)-susceptible DBA/2 mouse, the pentylenetetrazole (PTZ)-induced seizures in ICR-CD1 mice and the WAG/Rij rat as a genetic model of absence epilepsy with comorbidity of depression were used. Our results demonstrate that OJe was able to exert anticonvulsant effects on AGS-sensible DBA/2 mice and to inhibit PTZ-induced tonic seizures, increasing their latency. Conversely, it did not have anti-absence effects on WAG/Rij rats. Our experimental findings suggest that the anti-convulsant effects of OJe are likely mediated by both an inhibition of NMDA receptors at the glycine-binding site and an agonistic activity on benzodiazepine-binding site at GABAA receptors. This study provides evidences for the antiepileptic activity of OJe, and its results could be used as scientific basis for further researches aimed to develop novel complementary therapy for the treatment of epilepsy in a context of a multitarget pharmacological strategy.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Citraro, Rita" sort="Citraro, Rita" uniqKey="Citraro R" first="Rita" last="Citraro">Rita Citraro</name></noRegion><name sortKey="Aiello, Rossana" sort="Aiello, Rossana" uniqKey="Aiello R" first="Rossana" last="Aiello">Rossana Aiello</name><name sortKey="De Sarro, Giovambattista" sort="De Sarro, Giovambattista" uniqKey="De Sarro G" first="Giovambattista" last="De Sarro">Giovambattista De Sarro</name><name sortKey="Donato Di Paola, Eugenio" sort="Donato Di Paola, Eugenio" uniqKey="Donato Di Paola E" first="Eugenio" last="Donato Di Paola">Eugenio Donato Di Paola</name><name sortKey="Leo, Antonio" sort="Leo, Antonio" uniqKey="Leo A" first="Antonio" last="Leo">Antonio Leo</name><name sortKey="Lippiello, Pellegrino" sort="Lippiello, Pellegrino" uniqKey="Lippiello P" first="Pellegrino" last="Lippiello">Pellegrino Lippiello</name><name sortKey="Navarra, Michele" sort="Navarra, Michele" uniqKey="Navarra M" first="Michele" last="Navarra">Michele Navarra</name><name sortKey="Russo, Emilio" sort="Russo, Emilio" uniqKey="Russo E" first="Emilio" last="Russo">Emilio Russo</name><name sortKey="Santangelo, Ermenegildo" sort="Santangelo, Ermenegildo" uniqKey="Santangelo E" first="Ermenegildo" last="Santangelo">Ermenegildo Santangelo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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